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If you've been eyeing off an NAD drip, or wondering where your longevity money is better spent after 50, this conversation will help you cut through the hype.
Dogs and people age through the same biology, and the things proven to slow it down are still the everyday ones.
Dr Matt Kaeberlein is a biologist who has spent almost 30 years studying why we age. He is a professor at the University of Washington and co-founded the Dog Aging Project, which now follows 55,000 dogs and their owners across the United States. It all started with his German shepherd, Dobby, and one thought: some of the things that slow ageing in mice, flies and worms should work in dogs too.
This is the first of two parts with Matt. A lot of what we discuss is still being researched, so please don't start any medication or supplement without talking to your own doctor first.
In this episode:
- Why bigger animals live longer across species, but bigger dogs (and people) live shorter lives within a species
- IGF-1, body size and the rate of ageing
- What 55,000 dogs are showing us about exercise, dementia and social connection
- What rapamycin is, how it works on mTOR, and why it is not a miracle drug
- Biological age versus chronological age, and the hallmarks of ageing
- GLP-1s, SGLT2 inhibitors and estrogens: the drugs Matt is watching
- Calcium alpha-ketoglutarate, creatine and NAD precursors
- The risks of NAD infusions
Follow the guest
Dr Matt Kaeberlein
Instagram: https://www.instagram.com/mkaeberlein
Dog Aging Project: https://dogagingproject.org/
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Disclaimer: This podcast and any information, advice, opinions or statements within it do not constitute medical, health care or other professional advice. Information is provided for educational and entertainment purposes only.
00:00 Intro
03:31 How Matt came to study ageing
05:27 How Dobby led to the Dog Aging Project
06:25 Why do big dogs die younger than small dogs?
08:20 IGF-1 and body size
09:31 What 55,000 dogs are teaching us about exercise, dementia and social connection
11:44 Kibble, raw or home cooked, and feeding once a day
15:07 A word from Dr Shauna: the "Now What?" List
15:44 What ageing in dogs tells us about ageing in people
18:21 The rapamycin trial in dogs
19:11 What is rapamycin and how does it work?
23:37 Is rapamycin promising? Early results and side effects
26:21 What do we mean by ageing? Biological vs chronological age
28:21 The hallmarks of ageing
29:59 Can we really reverse ageing?
31:16 Caloric restriction and other ways to slow ageing
32:46 Why lifestyle still has the best evidence
33:57 Longevity drugs to watch: GLP-1s
34:55 SGLT2 inhibitors
36:13 Estrogens, HRT and the UK Biobank study
38:10 Supplements: alpha-ketoglutarate and creatine
39:46 NAD precursors
40:46 The risks of NAD infusions
43:54 Dr Shauna's three takeaways
Menopause
Midlife
Perimenopause
Dr Shauna Watts
Dr Shauna GP
Womens health advocate
Dr Matt Kaeberlein
Dog Aging Project
Longevity
Biology of ageing
Biological age
Hallmarks of ageing
Rapamycin
mTOR
Healthspan
Caloric restriction
GLP-1
SGLT2 inhibitors
Estrogen and ageing
HRT
Creatine
Calcium alpha-ketoglutarate
NAD infusions
NAD supplements
Dogs and ageing
ChaptersKeywords
